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KMID : 1098420170250050305
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Korean Journal of Medicinal Crop Science
2017 Volume.25 No. 5 p.305 ~ p.314
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Antioxidant Activity and NO Inhibitory Effect of Bioconverted Medicinal Material Using Germinated Green Rice and Hericium erinaceus Mycelium
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Lee Young-Min
Kim In-Sook
Mithun Ghosh
Hong Seong-Min
Lee Taek-Hwan
Lee Dong-Hee
Lim Beong-Ou
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Abstract
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Background: Hericium erinaceus is considered a functional food and potential medicinal source. The present study was conducted to examine the potential antioxidant and anti-inflammatory activities of carried out with water and ethanol extracts of Hericium erinaceus grown on germinated green rice (HEGR-W and HEGR-E, respectively) and the water and ethanol extracts of germinated green rice (GR-W and GR-E, respectively) as potential medicinal resources or antioxidant and anti-inflammatory agents.
Methods and Results: The total phenolic and flavonoid contents, DPPH, and ABTS activity, reducing power, DNA protective activity, cell viability, and NO production were investigated. The total phenolic and flavonoid contents were highest in HEGR-E(66.53 ± 2.40 ㎎·GAE/100 g and 82.12 ± 7.10 ㎎·CE/100 g respectively). HEGR-E exhibited high DPPH (44.70 ± 1.28%) and, ABTS (44.70 ± 1.28%) activity and reducing power (0.219). HEGR and GR extracts showed protective activity against DNA damage. The cytotoxicity of HEGR and GR in RAW264.7 cells and LPS-induced RAW264.7 cells was low. HEGR-E and GR-W exhibited anti-inflammatory effects through a 28% inhibition of NO production in LPS-induced RAW264.7 cells.
Conclusions: These results suggested that the extracts of Hericium erinaceus grown on germinated green rice could be a potential medicinal material with natural antioxidant and NO inhibitory properties.
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KEYWORD
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Hericium erinaceus, Antioxidant, DNA Protection, DPPH, Green Rice, NO
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